Bertrand Le Bourdonnec

Executive Biotech R&D Leader - Accomplished Drug Hunter & Developer

PROFESSIONAL PROFILE ▪ Seasoned R&D Executive, Drug Hunter & Developer ▪ Passionate about identifying innovative therapies, advancing them to the Clinic & demonstrating Clinical proof-of-concept ▪ 23 years discovery and development experience in start-up, small- & mid-size Biotech companies ▪ Broad leadership skills managing small & large (up to ~100 members) Teams across various:  Departments: Chemistry (synthetic, medicinal, analytical, computational, process) - Structural Biology - Compound library management & High Throughput Screening - Cheminformatics - CMC - ADME/DMPK - Toxicology - Safety Pharmacology - Program & Portfolio Management - Alliance Management  R&D Stages: Hit Finding, Hit-to-Lead, Lead Optimization, Pre-Clinical, Clinical, Post-Approval  Therapeutic area: Oncology, Pain, Gastroenterology, Infectious Diseases, Neurodegenerative Diseases R&D TRACK RECORD ▪ 12 Clinical/Pre-Clinical candidates ▪ 7 IND/CTA filings ▪ 36 Publications ▪ > 80 US/World patents BUSINESS FINANCE & CORPORATE EXPERIENCE ▪ Multi Million $ budget management ▪ Valuation of development & commercial assets (NPV) ▪ Business development & licensing ▪ Mergers & acquisitions ▪ Investor & media relations PROFESSIONAL PROFILE ▪ Seasoned R&D Executive, Drug Hunter & Developer ▪ Passionate about identifying innovative therapies, advancing them to the Clinic & demonstrating Clinical proof-of-concept ▪ 23 years discovery and development experience in start-up, small- & mid-size Biotech companies ▪ Broad leadership skills managing small & large (up to ~100 members) Teams across various:  Departments: Chemistry (synthetic, medicinal, analytical, computational, process) - Structural Biology - Compound library management & High Throughput Screening - Cheminformatics - CMC - ADME/DMPK - Toxicology - Safety Pharmacology - Program & Portfolio Management - Alliance Management  R&D Stages: Hit Finding, Hit-to-Lead, Lead Optimization, Pre-Clinical, Clinical, Post-Approval  Therapeutic area: Oncology, Pain, Gastroenterology, Infectious Diseases, Neurodegenerative Diseases R&D TRACK RECORD ▪ 12 Clinical/Pre-Clinical candidates ▪ 7 IND/CTA filings ▪ 36 Publications ▪ > 80 US/World patents BUSINESS FINANCE & CORPORATE EXPERIENCE ▪ Multi Million $ budget management ▪ Valuation of development & commercial assets (NPV) ▪ Business development & licensing ▪ Mergers & acquisitions ▪ Investor & media relations