Veralox is a clinical stage company developing drug products targeting the 12-Lipoxygenase pathway

12-lipoxygenase (12-LOX) is an enzyme that oxidizes fatty acids, generates proinflammatory metabolites and has been implicated in a myriad of diseases including Heparin-Induced Thrombocytopenia (HIT) and Type 1 Diabetes (T1D). We are developing therapies for these diseases with a clinical program in HIT, preclinical program in T1D and discovery research aimed at expanding our 12-LOX inhibitors to additional diseases.

HIT is a deadly syndrome characterized by hyperactivated platelets and a devastating pro-thrombotic state. Targeting 12-LOX inhibits the production of 12-HETE, a proinflammatory metabolite known to play a role in platelet activation and thrombosis. We received Orphan Designation and Fast Track Designation for our first-in-class drug product, VLX-1005, addressing the underlying cause of this immune-driven blood clotting.

We are developing a disease-modifying therapy for T1D. By inhibiting 12-LOX and shutting down production of its products like 12-HETE, β cells are able to function properly by producing more insulin and becoming more resilient to immune attack.